NDLI: Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.

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Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells.

Content Provider	Scilit
Author	Mesri, Enrique A. Cesarman, E. Arvanitakis, L. Rafii, S. Moore, M. A. Posnett, D. N. Knowles, D. M. Asch, A. S.
Copyright Year	1996
Description	Herpesviral DNA fragments isolated from AIDS-associated Kaposi's sarcoma (KS) tissue (KSHV-DNA) share homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus saimiri, and are present in the lesions of more than 95% of HIV and non-HIV-associated forms of KS, AIDS-related body cavity-based lymphomas, and AIDS-related multicentric Castleman's disease. Here we show that BC-1, a KSHV-DNA-positive, body cavity-based lymphoma cell line, produces infective herpesviral particles carrying a linear 270-kb genome that specifically transmits KSHV-DNA to CD19+ B cells. Transmission of KSHV-DNA is dependent upon a biologically active, replicating virus, since it is blocked by UV irradiation and foscarnet, an inhibitor of viral DNA-polymerase. This study represents the first isolation and transmission of the human herpesvirus-8/KS-associated herpesvirus.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192551/pdf
Ending Page	2390
Page Count	6
Starting Page	2385
DOI	10.1084/jem.183.5.2385
Journal	The Journal of experimental medicine
Issue Number	5
Volume Number	183
Language	English
Publisher	Rockefeller University Press
Publisher Date	1996-05-01
Access Restriction	Open
Subject Keyword	Virology Hiv Sarcoma Lymphoma Cavity Herpesvirus Dna Fragments Kshv Herpesviral Journal: The Journal of experimental medicine (Vol- 183, Issue- 5)
Content Type	Text

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