NDLI: Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]

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Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease [see comments]

Content Provider	Scilit
Author	D'agay, Mf Soulier, J. Grollet, L. Oksenhendler, E. Cacoub, P. Cazals-Hatem, D. Babinet, P. Clauvel, Jp Raphael, M. Degos, L. Sigaux, F.
Copyright Year	1995
Description	Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HIV)-associated MCD cases and also, but less frequently, in HIV-negative patients. Recently, sequences of a putative new Herpesvirus (KSHV) have been isolated and further detected in almost all the acquired immunodeficiency syndrome (AIDS) KS and in most of the non-AIDS KS samples. In this study, we searched for these Herpesvirus-like sequences in MCD samples of 31 patients. KSHV sequences were detected in 14 of 14 cases of HIV-associated MCD, including 5 cases without detectable KS. Moreover, KSHV was detected in 7 of 17 MCD cases in HIV-negative patients, including 1 case associated with a cutaneous KS. In 34 non-MCD reactive lymph nodes (follicular and/or interfollicular hyperplasia) in HIV-negative patients, KSHV was detected in only 1 case. In 1 HIV-negative case of MCD, KSHV was found in both the lymph node and peripheral blood samples. These data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients.
Related Links	https://ashpublications.org/blood/article-pdf/86/4/1276/617362/1276.pdf
Ending Page	1280
Page Count	5
Starting Page	1276
DOI	10.1182/blood.v86.4.1276.bloodjournal8641276
Journal	Blood
Issue Number	4
Volume Number	86
Language	English
Publisher	American Society of Hematology
Publisher Date	1995-08-15
Access Restriction	Open
Subject Keyword	Virology Hiv Sarcoma Lymph Mcd Node Multicentric Kshv Kaposi's Castleman's Journal: Blood (Vol- 77, Issue- 4)
Content Type	Text
Resource Type	Article

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