NDLI: Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies

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Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies

Content Provider	Scilit
Author	Muellenbeck, Matthias F. Ueberheide, Beatrix Amulic, Borko Epp, Alexandra Fenyo, David Busse, Christian Esen, Meral Theisen, Michael Mordmüller, Benjamin Wardemann, Hedda
Copyright Year	2013
Description	Antibodies can protect from Plasmodium falciparum (Pf) infection and clinical malaria disease. However, in the absence of constant reexposure, serum immunoglobulin (Ig) levels rapidly decline and full protection from clinical symptoms is lost, suggesting that B cell memory is functionally impaired. We show at the single cell level that natural Pf infection induces the development of classical memory B cells (CM) and atypical memory B cells (AtM) that produce broadly neutralizing antibodies against blood stage Pf parasites. CM and AtM contribute to anti-Pf serum IgG production, but only AtM show signs of active antibody secretion. AtM and CM were also different in their IgG gene repertoire, suggesting that they develop from different precursors. The findings provide direct evidence that natural Pf infection leads to the development of protective memory B cell antibody responses and suggest that constant immune activation rather than impaired memory function leads to the accumulation of AtM in malaria. Understanding the memory B cell response to natural Pf infection may be key to the development of a malaria vaccine that induces long-lived protection.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570107/pdf http://jem.rupress.org/content/210/2/389.full.pdf
Ending Page	399
Page Count	11
Starting Page	389
DOI	10.1084/jem.20121970
Journal	The Journal of experimental medicine
Issue Number	2
Volume Number	210
Language	English
Publisher	Rockefeller University Press
Publisher Date	2013-01-14
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antibody Vaccine Function Memory B Cells Malaria Atm Constant Natural Pf Journal: The Journal of experimental medicine (Vol- 210, Issue- 2)
Content Type	Text

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