NDLI: Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

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Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM

Content Provider	Scilit
Author	Hopp, Christine S. Sekar, Padmapriya Diouf, Ababacar Miura, Kazutoyo Boswell, Kristin Skinner, Jeff Tipton, Christopher M. Peterson, Mary E. Chambers, Michael J. Andrews, Sarah Lu, Jinghua Tan, Joshua Li, Shanping Doumbo, Safiatou Kayentao, Kassoum Ongoiba, Aissata Traore, Boubacar Sun, Peter D. Long, Carole Koup, Richard A. Long, Eric O. McDermott, Adrian B. Crompton, Peter D.
Copyright Year	2021
Description	IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitudinal analyses of Pf- and influenza-specific B cells. We found that Pf-specific memory B cells (MBCs) are disproportionally $IgM^{+}$ and only gradually shift to $IgG^{+}$ with age, in contrast to influenza-specific MBCs that are predominantly $IgG^{+}$ from infancy to adulthood. B cell receptor analysis showed Pf-specific IgM MBCs are somatically hypermutated at levels comparable to influenza-specific IgG B cells. During acute malaria, Pf-specific IgM B cells expand and upregulate activation/costimulatory markers. Finally, plasma IgM was comparable to IgG in inhibiting Pf growth and enhancing phagocytosis of Pf by monocytes in vitro. Thus, somatically hypermutated Pf-specific IgM MBCs dominate in children, expand and activate during malaria, and produce IgM that inhibits Pf through neutralization and opsonic phagocytosis.
Related Links	https://rupress.org/jem/article-pdf/218/4/e20200901/1411121/jem_20200901.pdf
DOI	10.1084/jem.20200901
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	218
Language	English
Publisher	Rockefeller University Press
Publisher Date	2021-03-04
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Children Somatically Igg Malaria Antibodies Sup Specific Igm B Cells Journal: The Journal of experimental medicine (Vol- 218, Issue- 4)
Content Type	Text

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