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MEMBRANE IMMUNOGLOBULINS OF B LYMPHOCYTES
| Content Provider | Scilit |
|---|---|
| Author | Fu, S. M. Kunkel, H. G. |
| Copyright Year | 1974 |
| Description | Hemagglutination and fluorescent antibody studies have provided strong evidence for the unavailability or absence of specific antigenic sites on membrane-bound IgM which are present in serum and intracellular IgM. Antisera specific for different parts of the molecule indicated that a portion but not all of the Fc was involved. Absorption experiments with normal and leukemic viable B lymphocytes failed to remove a population of Fc antibodies found in IgM-specific antisera. Similar findings were made for IgD, the other major membrane immunoglobulin of human peripheral blood B cells. Various interpretations of these observations are discussed. The most likely possibility appears that the C-terminal portion of the heavy chains of the immunoglobulin molecule is buried in the membrane. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139633/pdf http://jem.rupress.org/content/140/4/895.full.pdf |
| Ending Page | 903 |
| Page Count | 9 |
| Starting Page | 895 |
| DOI | 10.1084/jem.140.4.895 |
| Journal | The Journal of experimental medicine |
| Issue Number | 4 |
| Volume Number | 140 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1974-10-01 |
| Access Restriction | Open |
| Subject Keyword | Antibody Lymphocytes Igm Viable Antigenic Antisera Membrane Immunoglobulins Journal: The Journal of experimental medicine (Vol- 140, Issue- 4) |
| Content Type | Text |
