NDLI: HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor

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HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor

Content Provider	Scilit
Author	Dong, Tao Stewart-Jones, Guillaume Chen, Nan Easterbrook, Philippa Xu, Xiaoning Papagno, Laura Appay, Victor Weekes, Michael Conlon, Chris Spina, Celsa Little, Susan Screaton, Gavin Merwe, Anton Van Der Richman, Douglas D. McMichael, Andrew J. Jones, Yvonne Rowland-Jones, Sarah L.
Copyright Year	2004
Description	HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease progression we identified Vβ13.2 T cell receptors (TCRs) with very similar and unusually long β-chain complementarity determining region 3 (CDR3) regions in CTL specific for the immunodominant human histocompatibility leukocyte antigens (HLA)-B8–restricted human immunodeficiency virus-1 (HIV-1) nef epitope, FLKEKGGL (FL8). CTL expressing Vβ13.2 TCRs tolerate naturally arising viral variants in the FL8 epitope that escape recognition by other CTL. In addition, they expand efficiently in vitro and are resistant to apoptosis, in contrast to FL8–specific CTL using other TCRs. Selection of Vβ13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212004/pdf http://jem.rupress.org/content/200/12/1547.full.pdf
Ending Page	1557
Page Count	11
Starting Page	1547
DOI	10.1084/jem.20032044
Journal	The Journal of experimental medicine
Issue Number	12
Volume Number	200
Language	English
Publisher	Rockefeller University Press
Publisher Date	2004-12-20
Access Restriction	Open
Subject Keyword	Immunology Hiv Cytotoxic T Lymphocytes (ctl) T Cell Receptor Cross-reactivity Apoptosis Journal: The Journal of experimental medicine (Vol- 200, Issue- 12)
Content Type	Text

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