NDLI: Fibronectin expression is determined by the genotype of the transformed parental cells in heterokaryons between normal and transformed fibroblasts.

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Fibronectin expression is determined by the genotype of the transformed parental cells in heterokaryons between normal and transformed fibroblasts.

Content Provider	Scilit
Author	Laurila, Pekka Wartiovaara, Jorma Stenman, Svante
Copyright Year	1979
Description	The expression of fibronectin, a cell surface-associated transformation-sensitive glycoprotein, was studied in hetero- and homokaryons of normal and SV40-transformed human fibroblasts. In immunofluorescence, fibroblast homokaryons had an intense surface-associated and intracelluar fibronectin fluorescence similar to that of normal fibroblasts. Transformed cells and their homokaryons had a minimal surface-associated and a weak intracellular fibronectin fluorescence. In heterokaryons formed between transformed and normal fibroblasts, the expression of fibronectin fell within 24 h to the level of the transformed cell homokaryons. The change was detectable already at 3 h after fusion and was gene-dose dependent. These results show that the transformed genotype determines fibronectin expression in the heterokaryons.
Related Links	http://jcb.rupress.org/content/80/1/118.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110290/pdf
Ending Page	127
Page Count	10
Starting Page	118
DOI	10.1083/jcb.80.1.118
Journal	Journal of Cell Biology
Issue Number	1
Volume Number	80
Language	English
Publisher	Rockefeller University Press
Publisher Date	1979-01-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Fibronectin Heterokaryon Malignant Transformation �9 Phenotypic Regulation �9 Fibroblast Cell Fusion Glycoproteins Cell Line Genotype Membrane Proteins Journal: Journal of Cell Biology (Vol- 80, Issue- 1)
Content Type	Text

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