NDLI: External fibronectin of cultured human fibroblasts is predominantly a matrix protein.

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External fibronectin of cultured human fibroblasts is predominantly a matrix protein.

Content Provider	Scilit
Author	Hedman, Klaus Vaheri, Antti Wartiovaara, Jorma
Copyright Year	1978
Description	Journal: Journal of Cell Biology The distribution of a major glycoprotein (fibronectin) of human fibroblast cultures was studied in immunoelectron microscopy with peroxidase- or ferritin-labeled antibodies. External fibronectin was visualized in pericellular structures, in some areas on the growth substratum, and to a lesser degree in close association with the upper and lower surface membranes of the cell. The pericellular fibronectin-containing structures consisted of amorphous or vaguely fibrillar material forming strands or patches, 50-500 nm in diameter; the structures appeared to mediate distant cell-to-cell and cell-to-substrate contacts. When in close association with the plasma membrane, fibronectin markers were seen as discrete patches. The exact relationship between this form of fibronectin and the plasma membrane, however, remained open. Filamentous material was commonly seen in the cortical cytoplasm under patches of membrane-associated fibronectin. The distribution that we observed is consistent with the proposed roles of fibronectin in cell interactions with neighboring structures and with its presence in vivo as an extracellular glycoprotein in connective tissue matrix and basal laminae.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2109997/pdf http://jcb.rupress.org/content/76/3/748.full.pdf
ISSN	00221295
DOI	10.1083/jcb.76.3.748
Journal	Journal of Cell Biology
Issue Number	3
Volume Number	76
Language	English
Publisher	Rockefeller University Press
Publisher Date	1978-03-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Cell Biology Microscopic Research Immunoelectron Intercellular Basement Membrane �9 Cell Surface Connective Tissue Fibroblast Cell Adhesion Glycoprotein Cell Line Membrane Proteins Connective Tissue Glycoproteins
Content Type	Text
Resource Type	Article
Subject	Physiology

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