NDLI: Modulation of fibronectin gene expression in chondrocytes by viral transformation and substrate attachment.

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Modulation of fibronectin gene expression in chondrocytes by viral transformation and substrate attachment.

Content Provider	Scilit
Author	Adams, S. L. Pacifici, M. Boettiger, D. Pallante, K. M.
Copyright Year	1987
Description	Chicken vertebral chondrocytes, which normally grow in suspension, synthesize large amounts of cartilage extracellular matrix proteins, but little fibronectin. We have analyzed the effects of both substrate attachment and transformation with a temperature-sensitive mutant of Rous sarcoma virus on fibronectin gene expression in these cells. Our experiments show that viral transformation increases fibronectin synthesis to a greater extent than substrate attachment. Furthermore, transformed chondrocytes have lost the ability to decrease fibronectin synthesis in response to suspension culture, suggesting that transformation alters the normal attachment-responsive control of fibronectin gene expression. Finally, infected substrate-attached chondrocytes shifted to the nonpermissive temperature for transformation use fibronectin RNA more efficiently in protein synthesis than cells grown under the other conditions, suggesting for the first time a role for translational control of fibronectin gene expression.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114916/pdf http://jcb.rupress.org/content/105/1/483.full.pdf
Ending Page	488
Page Count	6
Starting Page	483
DOI	10.1083/jcb.105.1.483
Journal	Journal of Cell Biology
Issue Number	1
Volume Number	105
Language	English
Publisher	Rockefeller University Press
Publisher Date	1987-07-01
Access Restriction	Open
Subject Keyword	Virology Transformation Proteins Chondrocytes Fibronectin Gene Expression Substrate Attachment Journal: Journal of Cell Biology (Vol- 105, Issue- 1)
Content Type	Text

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