NDLI: Arginine methylation of the B cell antigen receptor promotes differentiation

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Arginine methylation of the B cell antigen receptor promotes differentiation

Content Provider	Scilit
Author	Infantino, Simona Benz, Beate Waldmann, Tanja Jung, Manfred Schneider, Robert Reth, Michael
Copyright Year	2010
Description	Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igα subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igα arginine methylation can play an important role in specifying the outcome of BCR signaling.
Related Links	http://jem.rupress.org/content/jem/207/4/711.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856019/pdf
Ending Page	719
Page Count	9
Starting Page	711
DOI	10.1084/jem.20091303
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	207
Language	English
Publisher	Rockefeller University Press
Publisher Date	2010-03-15
Access Restriction	Open
Subject Keyword	Immunology Antigen Differentiation Methylation Protein Arginine Lymphocytes Kinase Specifying Methyltransferase Tail Journal: The Journal of experimental medicine (Vol- 207, Issue- 4)
Content Type	Text

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