NDLI: IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

Content Provider	Scilit
Author	D'costa, Kathy Zotos, Dimitra Coquet, Jonathan Zhang, Yang Light, Amanda Kallies, Axel Corcoran, Lynn M. Godfrey, Dale Toellner, Kai-Michael Smyth, Mark Nutt, Stephen Tarlinton, David M.
Copyright Year	2010
Description	Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection of variants with improved affinity for antigen. Long-lived memory B cells and plasma cells are also generated in GCs, although how B cell differentiation in GCs is regulated is unclear. IL-21, secreted by T follicular helper cells, is important for adaptive immune responses, although there are conflicting reports on its target cells and mode of action in vivo. We show that the absence of IL-21 signaling profoundly affects the B cell response to protein antigen, reducing splenic and bone marrow plasma cell formation and GC persistence and function, influencing their proliferation, transition into memory B cells, and affinity maturation. Using bone marrow chimeras, we show that these activities are primarily a result of CD3-expressing cells producing IL-21 that acts directly on B cells. Molecularly, IL-21 maintains expression of Bcl-6 in GC B cells. The absence of IL-21 or IL-21 receptor does not abrogate the appearance of T cells in GCs or the appearance of CD4 T cells with a follicular helper phenotype. IL-21 thus controls fate choices of GC B cells directly.
Related Links	http://jem.rupress.org/content/207/2/365.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822601/pdf
Ending Page	378
Page Count	14
Starting Page	365
DOI	10.1084/jem.20091777
Journal	The Journal of experimental medicine
Issue Number	2
Volume Number	207
Language	English
Publisher	Rockefeller University Press
Publisher Date	2010-02-08
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Differentiation Somatic Protein Mode of Action Bone Marrow Adaptive Antigen Gcs Regulates Germinal Journal: The Journal of experimental medicine (Vol- 207, Issue- 2)
Content Type	Text

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