NDLI: MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

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MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

Content Provider	Scilit
Author	Quintavalle, Manuela Elia, Leonardo Condorelli, Gianluigi Courtneidge, Sara A.
Copyright Year	2010
Description	Smooth muscle cell (SMC) plasticity plays an important role during development and in vascular pathologies such as atherosclerosis and restenosis. It was recently shown that down-regulation of microRNA (miR)-143 and -145, which are coexpressed from a single promoter, regulates the switch from contractile to synthetic phenotype, allowing SMCs to migrate and proliferate. We show in this study that loss of miR-143/145 in vitro and in vivo results in the formation of podosomes, which are actin-rich membrane protrusions involved in the migration of several cell types, including SMCs. We further show that platelet-derived growth factor (PDGF) mediates podosome formation in SMCs through the regulation of miR-143/145 expression via a pathway involving Src and p53. Moreover, we identify key podosome regulators as targets of miR-143 (PDGF receptor α and protein kinase C ε) and miR-145 (fascin). Thus, dysregulation of the miR-143 and -145 genes is causally involved in the aberrant SMC plasticity encountered during vascular disease, in part through the up-regulation of an autoregulatory loop that promotes podosome formation.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854384/pdf http://jcb.rupress.org/content/189/1/13.full.pdf
Ending Page	22
Page Count	10
Starting Page	13
DOI	10.1083/jcb.200912096
Journal	Journal of Cell Biology
Issue Number	1
Volume Number	189
Language	English
Publisher	Rockefeller University Press
Publisher Date	2010-03-29
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Plasticity Microrna Podosome Formation Smcs Migration Smooth Pdgf Vascular Protein Journal: Journal of Cell Biology (Vol- 189, Issue- 1)
Content Type	Text

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