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p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells
| Content Provider | Scilit |
|---|---|
| Author | Mak, Alan S. |
| Copyright Year | 2011 |
| Description | The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p53 in the curtailment of tumor progression and colonization of secondary sites by negatively regulating tumor cell metastasis ( 4;5) . Recently, we have found that p53 suppresses Src-induced formation of podosomes and associated invasive phenotypes in fibroblasts and vascular smooth muscle cells (VSMC) ( 6;7) . In this review, I will focus on some recent studies that have identified p53 as a suppressor of cell migration and invasion in general, and VSMC podosome formation and ECM degradation in particular. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cam.5.2.14375?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084980/pdf |
| Ending Page | 149 |
| Page Count | 6 |
| Starting Page | 144 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.5.2.14375 |
| Journal | Cell adhesion & migration |
| Issue Number | 2 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Developmental Biology Transcription Factor Metastasis Apoptosis Invasion Stress Suppressor Vascular Smooth Podosome P53 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
