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Red blood cell exchange in sickle cell disease patient with multiple alloantibodies
| Content Provider | Scilit |
|---|---|
| Author | Tiwari, Aseem Kumar Aggarwal, Geet Dhiman, Pratibha Arora, Dinesh Setya, Divya Pabbi, Swati Mehta |
| Copyright Year | 2020 |
| Abstract | There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination technique. 3-cell and 11- cell panel were used for antibody screening and identification, respectively. Automated RBC exchange was performed on apheresis machine Com.Tec using the standard PL1 kit (Fresenius Kabi, Germany). Multiple (anti-c, E) allo-antibodies were identified and successful pre-operative RCE was done with corresponding antigen-negative AHG compatible RBC units. Single RCE procedure reduced HbS concentration from 65% to 25%. The patient underwent uneventful hemi-arthroplasty and was discharged on post-operative day-7. Patient is on regular follow-up and continues to do well two months after the day of surgery. This is possibly the first case report from India, which illustrates successful automated RCE in a SCD patient with alloimmunization. |
| Related Links | http://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=70;epage=73;aulast=Aggarwal;type=2 |
| Ending Page | 73 |
| Page Count | 4 |
| Starting Page | 70 |
| File Format | XHTML |
| ISSN | 09736247 |
| e-ISSN | 19983565 |
| DOI | 10.4103/ajts.ajts_36_18 |
| Journal | Asian Journal of Transfusion Science |
| Issue Number | 1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2020-01-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Alloimmunization Red Blood Cell Exchange Sickle Cell Disease Sickle Hemoglobin Asian Journal of Transfusion Science, Volume 14, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Hematology |
