NDLI: Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease

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Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease

Content Provider	Scilit
Author	Tatari-Calderone, Zohreh Gordish-Dressman, Heather Fasano, Ross Riggs, Michael Fortier, Catherine Campbell, Andrew D. Charron, Dominique Gordeuk, Victor R. Luban, Naomi L. C. Vukmanovic, Stanislav Tamouza, Ryad
Copyright Year	2016
Description	Journal: Human immunology Alloimmunization or the development of alloantibodies to Red Blood Cell (RBC) antigens is considered one of the major complications after RBC transfusions in patients with sickle cell disease (SCD) and can lead to both acute and delayed hemolytic reactions. It has been suggested that polymorphisms in HLA genes, may play a role in alloimmunization. We conducted a retrospective study analyzing the influence of HLA-DRB1 and DQB1 genetic diversity on RBC-alloimmunization. Two-hundred four multi-transfused SCD patients with and without RBC-alloimmunization were typed at low/medium resolution by PCR-SSO, using IMGT-HLA Database. HLA-DRB1 and DQB1 allele frequencies were analyzed using logistic regression models, and global p-value was calculated using multiple logistic regression. While only trends towards associations between HLA-DR diversity and alloimmunization were observed, analysis of HLA-DQ showed that HLA-DQ2 (p=0.02), -DQ3 (p=0.02) and -DQ5 (p=0.01) alleles were significantly higher in non-alloimmunized patients, likely behaving as protective alleles. In addition, multiple logistic regression analysis showed both HLA-DQ2/6 (p=0.01) and HLA-DQ5/5 (p=0.03) combinations constitute additional predictor of protective status. Our data suggest that particular HLA-DQ alleles influence the clinical course of RBC transfusion in patients with SCD, which could pave the way towards predictive strategies.
Related Links	http://europepmc.org/articles/pmc4747802?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747802/pdf
Ending Page	40
Page Count	6
Starting Page	35
ISSN	01988859
e-ISSN	18791166
DOI	10.1016/j.humimm.2015.10.010
Journal	Human immunology
Issue Number	1
Volume Number	77
Language	English
Publisher	Elsevier BV
Publisher Date	2016-01-01
Access Restriction	Open
Subject Keyword	Journal: Human immunology Medical Laboratory Technology Red Blood Cell Transfusion Sickle Cell Disease
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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