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Phytochemical investigation of bauhinia winitii based on alpha-glucosidase inhibitory effect and molecular docking affirmation
| Content Provider | Scilit |
|---|---|
| Author | Rais, Ichwan Ridwan Pitakbut, Thanet Wattanapiromsakul, Chatchai Dej-Adisai, Sukanya |
| Copyright Year | 2021 |
| Abstract | Background: Bauhinia winitii (BW) (Fabaceae) plant revealed poor phytochemical investigation and anti-diabetic report. As one of the Bauhinia family which known with abundant flavonoids content, contrary, BW was only used for the treatment of diarrhea in Thai conservative remedy. Objectives: The aim of this study was to investigate the phytochemical constituents and anti-alpha glucosidase activity of BW. Materials and Methods: Phytochemical study was based on the alpha-glucosidase inhibitory effect. Isolated compounds were determined by chromatographic and spectroscopic techniques. The alpha-glucosidase enzymatic inhibitory test was then connected with molecular docking affirmation. Results: The ethyl acetate and ethanol extracts from leaves and woods exhibited the strongest activity with above 60% inhibition. Six compounds were isolated from these extracts, naringenin (1), luteolin (2), isoquercitrin (3), griffonilide (4), lithospermoside (5), and epi-β amyrin (6). The alpha-glucosidase inhibitory test showed that flavonoids performed potential results with naringenin as the highest $IC_{50}$ on 0.41 mM. The docking ensured the flavonoids activated at the same binding of alpha-glucosidase enzyme active site. Conclusion: This study would be the first report of chemical constituents from BW with its isolated compounds was presented anti-diabetic activity as alpha-glucosidase inhibitors. |
| Related Links | http://www.phcog.com/article.asp?issn=0973-1296;year=2021;volume=17;issue=76;spage=666;epage=672;aulast=Dej-adisai;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/pm.pm_204_21 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 76 |
| Volume Number | 17 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Alpha-glucosidase Inhibitor Anti-diabetes Bauhinia Winitii Molecular Docking Phytochemical Investigation Pharmacognosy Magazine, Volume 17, Issue 76 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
