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Pharmacognosy and pharmacology of Calotropis gigantea for discovery of anticancer therapeutics
| Content Provider | Scilit |
|---|---|
| Author | Kumar, Arun H. S. Khosravi, Zahra |
| Copyright Year | 2021 |
| Abstract | Background: Calotropis gigantea (CG) is a shrubby plant which is traditionally used for the treatment of diseases affecting the nervous system, digestive system, and skin. Several bioactive compounds from CG are isolated and investigated for their pharmacological properties. Methods: A systematic analysis of PubMed, Google Scholar, and PubChem database was performed, and the pharmacognosy and pharmacological properties of CG compounds were correlated. Results: Major phytochemicals such as those of the cardenolide, uscharin, and calotropin family were dominant in the CG plant. Phytochemicals found in the leaves, root, and latex of CG plant showed selective cytotoxicity, proapoptotic effects, and cell cycle arrest potential by modulating hypoxia-inducible factor 1 α, inhibitor of nuclear factor kappa-B kinase subunit beta (IKK-β), Notch, and Wnt signaling. Conclusion: The selective cytotoxicity against neuronal tumors, together with their neurogenesis/synaptogenesis potential and drug candidate like features merit the development of CG compounds as therapeutics for neuronal tumors. |
| Related Links | http://www.phcog.com/article.asp?issn=0973-1296;year=2021;volume=17;issue=6;spage=123;epage=128;aulast=Khosravi;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/pm.pm_166_21 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 6 |
| Volume Number | 17 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Anti-cancer Drugs Apoptosis Calotropis Gigantea Pharmacognosy Regeneration Synaptogenesis Pharmacognosy Magazine, Volume 17, Issue 6 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
