NDLI: A new sucrase enzyme inhibitor fromAzadirachta indica

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A new sucrase enzyme inhibitor fromAzadirachta indica

Content Provider	Scilit
Author	Bader, Ammar Youns, Mahmoud A. Abdelhady, Mohamed I. S. Shaheen, Usama
Copyright Year	2016
Abstract	Background: Sucrase enzyme inhibitor considered as an oral anti-diabetic therapy that delays the absorption of eaten carbohydrates, reducing the postprandial glucose and insulin peaks to reach normoglycemia. Materials and Methods: Chromatographic fractionation of the hydroalcoholic extract of leaves of Azadirachta indica growing in KSA, followed by in-vitro assay of sucrase enzyme inhibition activity. Results: This investigation led to the isolation of a new remarkable sucrase enzyme inhibitor; 4`-methyl Quercetin-7-O-β-D-glucuronopyranoside (1) alongside with four known compounds; 2,3-hexahydroxydiphenoyl-(α/β)-D-^{4}$C_{1}$ -glucopyranose (2), Avicularin (3), Castalagin (4) and Quercetin-3-O-glucoside (5). The structure of the new compound (1) was elucidated on the basis of its spectral data, including ESI-MS, UV,$ ^{1}$H NMR,$ ^{13}$C NMR,$ ^{1}$H-$ ^{1}$H COSY, HSQC, NOESY and HMBC. Conclusion: Under the assay conditions, hydroalcoholic extract of A. indica and compounds 1-5 exhibited significant sucrase enzyme inhibitory activity.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971946/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=46;spage=293;epage=296;aulast=Abdelhady;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/0973-1296.185705
Journal	Pharmacognosy Magazine
Issue Number	46
Volume Number	12
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Azadirachta Indica Polyphenols Sucrase Inhibitor Pharmacognosy Magazine, Volume 12, Issue 46
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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