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Chemical constituents and toxicological studies of leaves from Mimosa caesalpiniifolia Benth., a Brazilian honey plant
| Content Provider | Scilit |
|---|---|
| Author | Costa, Luciana Muratori Arcanjo, Daniel Dias Rufino Costa, Amilton Paulo Raposo Lustosa, Maria Do Carmo Gomes Rodrigues, KlingerAntônio da França Carvalho, Fernando Aéciode Amorim Ant, ônia Mariadas Graças Lopes Citó Bruno, Quirino Araújo Nayana, BrunaNery Monção |
| Copyright Year | 2014 |
| Abstract | Background: Mimosa caesalpiniifolia Benth. (Leguminosae) is widely found in the Brazilian Northeast region and markedly contributes to production of pollen and honey, being considered an important honey plant in this region. Objective: To investigate the chemical composition of the ethanol extract of leaves from M. caesalpiniifolia by GC-MS after derivatization (silylation), as well as to evaluate the in vitro and in vivo toxicological effects and androgenic activity in rats. Materials and Methods: The ethanol extract of leaves from Mimosa caesalpiniifolia was submitted to derivatization by silylation and analyzed by gas chromatography-mass spectrometry (GC-MS) to identification of chemical constituents. In vitro toxicological evaluation was performed by MTT assay in murine macrophages and by Artemia salina lethality assay, and the in vivo acute oral toxicity and androgenic evaluation in rats. Results: Totally, 32 components were detected: Phytol-TMS (11.66%), lactic acid-2TMS (9.16%), α-tocopherol-TMS (7.34%) and β-sitosterol-TMS (6.80%) were the major constituents. At the concentrations analyzed, the ethanol extract showed low cytotoxicity against brine shrimp (Artemia salina) and murine macrophages. In addition, the extract did not exhibit any toxicological effect or androgenic activity in rats. Conclusions: The derivatization by silylation allowed a rapid identification of chemical compounds from the M. caesalpiniifolia leaves extract. Besides, this species presents a good safety profile as observed in toxicological studies, and possess a great potential in the production of herbal medicines or as for food consumption. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189258/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2014;volume=10;issue=39;spage=456;epage=462;aulast=Mon |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.139773 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 39 |
| Volume Number | 10 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Cytotoxicity Derivatization Gc-ms Leguminosae Mimosa Caesalpiniifolia Pharmacognosy Magazine, Volume 10, Issue 39 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
