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Cytotoxic Effects of Ethyl Acetate Extract ofSambucus ebulusCompared With Etoposide on Normal and Cancer Cell Lines
| Content Provider | Scilit |
|---|---|
| Author | Saravi, Ss Saeedi Mirzayi, M. Shokrzadeh, M. |
| Copyright Year | 2009 |
| Abstract | Sambucus ebulus is a native botany and exists in large amount in Iran and consists of anti-cancer substances such as ebulin (RIP-II, ribosome inactivated protein-II), flavonoids, etc. Isolation and identification of some potent anti-tumor compounds from medicinal plants, has motivated researchers to screen different parts of plant species for anti-tumor effects. In previous studies, anti-inflammatory effects of n-hexane and methanolic extracts of S. ebulus , nephro- and hepato-toxic effects of ethylacetate extract of this plant and evaluation of role of vitamins C and E on prevention of cellular and pathological disorders induced by the ethyl acetate extract was performed and reported. So, cytotoxic activity and $IC_{50}$ of specific concentrations of ethyl acetate extract of fruits of S.ebulus on 4 normal and cancer cell lines was studied. Also, Etoposide, a chemotherapeutic drug, was administered to control positive group. The normal cell lines were CHO and rat fibroblast and cancer cell lines were HepG2 and CT26. The cytotoxic effects and $IC_{50}$ of the extract on the cell lines were studied followed by MTT assay. The results showed that the ethyl acetate extract of Sambucus ebulus possesses lower $IC_{50}$ in the cancer cell lines in comparison with the normal cell lines. On the other hand, the extract possesses higher IC 50 in comparison with Etoposide on all 4 normal and cancer cell lines (P |
| Related Links | http://www.phcog.com/article.asp?issn=0973-1296;year=2009;volume=5;issue=20;spage=316;epage=319;aulast=Shokrzadeh;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.58152 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 20 |
| Volume Number | 5 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Sambucus Ebulus Etoposide Cytotoxicity Mtt Assay Cell Line Pharmacognosy Magazine, Volume 5, Issue 20 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
