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Clinical profile of ST-elevation myocardial infarction thrombolysed with tenecteplase in Coronavirus Disease 2019 Pandemic: A comparative study
| Content Provider | Scilit |
|---|---|
| Author | Jena, Kamal Kant Manohar, G. Elamaran, C. Rudrappa, A. |
| Copyright Year | 2021 |
| Abstract | Background: Coronavirus disease-2019 (COVID-19) pandemic has affected millions worldwide. The various complications of COVID-19 have been discussed in the recent studies. We would like to discuss about one such cardiovascular complication, ST elevation myocardial infarction (STEMI) in COVID-19, and its characteristics in this article. Methodology: An observational study was done from April 1, 2020, to July 15, 2020, selecting all STEMI patients admitted to a tertiary care center in Chennai and treated with tenecteplase were grouped in to COVID-19 positive and negative. Their presenting features and complications and outcome were studied. Results: A total of 300 patients were admitted with STEMI during the study period, of which 11.66% were COVID-19 positive. Atherosclerotic cardiovascular risk factors were much lower in COVID-19-positive STEMI patients when compared to non-COVID STEMI patients. Mean oxygen saturation at time of presentation in COVID-19 positive and negative patients was 85.1% and 97.5%, respectively (P < 0.001). COVID-19 group had significantly higher noncardiac complications than non-COVID patients (P < 0.001). The average duration of hospital stay in COVID-19 STEMI was 13.6 days, whereas in non-COVID group was 6.8 days (P < 0.001). Higher mortality was found in the COVID-19 positive group (14.28%) when compared to non-COVID STEMI (7.9%; P < 0.001). Conclusion: COVID-19 itself is a systemic inflammatory disease, which could increase the risk of coronary plaque rupture. Thrombosis has also been described as a mechanism underlying certain cases causing presentation of STEMI, because of endothelial dysfunction and hypercoagulable state. |
| Related Links | https://www.jcpconline.org/article.asp?issn=2250-3528;year=2021;volume=10;issue=2;spage=58;epage=62;aulast=Jena;type=2 |
| File Format | XHTML |
| ISSN | 22503528 |
| DOI | 10.4103/jcpc.jcpc_64_20 |
| Journal | Journal of Clinical and Preventive Cardiology |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Cardiology and Cardiovascular Diseases Acute Myocardial Infarction Coronavirus Disease-2019 Fibrinolysis Hypercoagulability Risk Factors Journal of Clinical and Preventive Cardiology, Volume 10, Issue 2 |
| Content Type | Text |
| Resource Type | Article |
