Profile of acute ST-elevation myocardial infarction patients with hyponatremia

Content Provider	Scilit
Author	Devi, Konsam Biona Chanu, Keisham Jaya Ram, Ratan Narayanaswamy, Gopinath Chongtham, Dhanaraj Singh Singh, Ksh Birendra
Copyright Year	2017
Abstract	Context: In acute ST-elevation myocardial infarction (STEMI), hyponatremia occurs due to neurohormonal activation. Magnitude of this neurohormonal change is related to the severity of myocardial damage. Aims: This study aimed to document the profile of STEMI with hyponatremia and to evaluate the correlation of hyponatremia with Killip class, creatine kinase-muscle brain (CK-MB) level, and degree of ST-elevation. Settings and Design: A longitudinal study was conducted in a tertiary care teaching hospital, Imphal. Patients and Methods: The study included 100 patients with STEMI. Killip class was ascertained on admission. Serum sodium level was estimated on admission, after 24 h, 48 h, and 72 h. CK-MB level was estimated, and the degree of ST-elevation was measured. Statistical Analysis: Statistical Package for the Social Sciences (SPSS 16.0 version) and Student's t-test, Chi-square test, and Fisher's exact test were used for statistical analysis. P < 0.05 was considered statistically significant. Results: Hyponatremia was observed in 44% of the patients. There was no significant relation of hyponatremia with comorbidities such as hypertension, diabetes mellitus, and dyslipidemia. Hyponatremia was associated with Killip III and IV (P = 0.00), higher CK-MB level (P = 0.010), and higher degree of ST-elevation (P = 0.002). Out of six in-hospital deaths, four had hyponatremia. Conclusion: Since hyponatremia was found to be associated with higher Killip class, elevated CK-MB level, and greater degree of ST-segment elevation, it can be speculated that hyponatremia in STEMI patients can be a predictor of poor outcome. Therefore, serum sodium levels can serve as a simple marker to identify patients at high risk.
Related Links	http://www.jmedsoc.org/article.asp?issn=0972-4958;year=2017;volume=31;issue=2;spage=119;epage=122;aulast=Devi;type=2
File Format	XHTML
ISSN	09724958
DOI	10.4103/jms.jms_83_15
Journal	Journal of Medical Society
Issue Number	2
Volume Number	31
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Cardiology and Cardiovascular Diseases Hyponatremia Killip Class Neurohormonal Activation St-elevation Myocardial Infarction Journal of Medical Society, Volume 31, Issue 2
Content Type	Text
Resource Type	Article
Subject	Medicine