NDLI: Mechanism of action of isolated caffeic acid and epicatechin 3-gallate from Euphorbia hirta against Pseudomonas aeruginosa

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Mechanism of action of isolated caffeic acid and epicatechin 3-gallate from Euphorbia hirta against Pseudomonas aeruginosa

Content Provider	Scilit
Author	Perumal, Shanmugapriya Mahmud, Roziahanim Ismail, Sabariah
Copyright Year	2017
Abstract	Background: The escalating dominance of resistant Pseudomonas aeruginosa strains as infectious pathogen had urged the researchers to look for alternative and complementary drugs. Objective: The objective of this study is to address the biological targets and probable mechanisms of action underlying the potent antibacterial effect of the isolated compounds from Euphorbia hirta (L.) against P. aeruginosa. Materials and Methods: The action mechanisms of caffeic acid (CA) and epicatechin 3-gallate (ECG) on P. aeruginosa cells were investigated by several bacterial physiological manifestations involving outer membrane permeabilization, intracellular potassium ion efflux, and nucleotide leakage. Results: The findings revealed that ECG and CA targeted both cell wall and cytoplasmic membrane of P. aeruginosa. The cellular membrane destruction and ensuing membrane permeability perturbation of P. aeruginosa had led to the ascending access of hydrophobic antibiotics, release of potassium ions, and leakages of nucleotides. Conclusion: The overall study concludes that ECG and CA isolated from E. hirta possess remarkable anti-infective potentials which can be exploited as drug template for the development of new antibacterial agent against resistant P. aeruginosa pathogen. Abbreviations used: ECG: Epicatechin 3-gallate; CA: Caffeic acid; E. hirta: Euphoria hirta.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538172/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=50;spage=311;epage=315;aulast=Perumal;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/pm.pm_309_15
Journal	Pharmacognosy Magazine
Issue Number	50
Volume Number	13
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Erythromycin Euphorbia Hirta (l.) Nucleotide Leakage Potassium Ion Efflux Rifampicin Pharmacognosy Magazine, Volume 13, Issue 50
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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