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The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial
| Content Provider | Scilit |
|---|---|
| Author | Akhondzadeh, Shahin Milajerdi, Alireza Jazayeri, Shima Shirzadi, Elham Derakhshan, Zhaleh Djazayeri, Abolghassem Hashemzadeh, Najmeh |
| Copyright Year | 2018 |
| Abstract | Background: Metabolic control is a major concern in preventing diabetic complications. Saffron as a natural source of antioxidants could play a role in alleviating diabetes insults. The aim of this study was to investigate effect of saffron hydroalcoholic extract on metabolic control in type 2 diabetes (T2D) mellitus. Materials and Methods: This randomized triple blind study was included 54 T2D patients which randomly received either saffron (Group 1) or placebo (Group 2) twice daily other than routine antidiabetic treatments for 8 weeks. Serum concentration of fasting blood sugar (FBS), 2-h plasma glucose, hemoglobin A1c (HbA1c), total cholesterol, triglyceride (TG), low-density lipoprotein, and high-density lipoprotein were measured as the markers of metabolic control. Anthropometric measures and blood pressure were also measured at the baseline, every 2 weeks during the intervention and the end of the study. Data analyzed using repeated measure analysis of variance test. Results: The baseline metabolic parameters were the same in two group (P > 0.01). FBS serum level significantly decreased within 8 weeks in the saffron group (128.84 ± 31.86) as compared to the placebo (153.76 ± 41.23), (P < 0.001). There was no statistical difference in other metabolic parameters such as serum lipids, blood pressure, and HbA1c (P > 0.01). Conclusion: Saffron hydroalcoholic extract may improve blood glucose control by reducing FBS in T2D patients. However, saffron extract has no significant effect on other aspects of diabetic control in diabetic patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842443/pdf |
| File Format | XHTML |
| ISSN | 17351995 |
| e-ISSN | 17357136 |
| DOI | 10.4103/jrms.jrms_286_17 |
| Journal | Journal of Research in Medical Sciences |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Diabetes Mellitus Fasting Blood Glucose Lipid Metabolic Syndrome Saffron Extract Journal of Research in Medical Sciences, Volume 23, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
