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Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
| Content Provider | Scilit |
|---|---|
| Author | Ebrahimi, Fatemeh Sahebkar, Amirhossein Aryaeian, Naheed Pahlavani, Naseh Fallah, Soudabeh Moradi, Nariman Abbasi, Davoud Hosseini, Agha Fatemeh |
| Copyright Year | 2019 |
| Description | Background: Type 2 diabetes (T2D) is accompanied by elevated inflammation, oxidative stress, hyperlipidemia and hyperglycemia which all contribute to cardiovascular disease pathogenesis. Saffron as a complementary medicine and source of antioxidants could play a role in alleviating diabetes and its complications. The aim of this study was to determine the effects of saffron supplementation as an adjunct therapy in T2D. Patients and methods: This randomized controlled trial included 80 T2D patients with a mean age of 54.1 years. Participants were randomly assigned into two groups to take either saffron tablets (100 mg/day; n=40) or placebo (n=40) for 12 weeks. Fasting blood samples were obtained at the beginning and after the intervention period to quantify glycemic factors, lipid profile, and biomarkers of inflammation and oxidative stress. Anthropometric indices and dietary intakes were also measured at baseline and at study end. Results: Compared with placebo, saffron supplementation resulted in significant decreases in waist circumference (p0.05). Conclusion: Overall, 12 weeks of saffron supplementation in diabetic patients had beneficial effects on waist circumference and serum MDA levels. However, saffron did not influence other evaluated cardio metabolic risk markers in diabetic patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798815/pdf https://www.dovepress.com/getfile.php?fileID=53274 |
| Ending Page | 2115 |
| Page Count | 9 |
| Starting Page | 2107 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s216666 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Integrative and Complementary Medicine Crocus Sativus Diabetes Mellitus Dysglycemia Inflammation Mediators Lipid Profile Type 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
