Loading...
Please wait, while we are loading the content...
Similar Documents
Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels
| Content Provider | Scilit |
|---|---|
| Author | Bertassoni, Luiz E. Cardoso, Juliana C. Manoharan, Vijayan Cristino, Ana L. Bhise, Nupura S. Araujo, Wesleyan A. Zorlutuna, Pinar Vrana, Nihal E. Ghaemmaghami, Amir M. Dokmeci, Mehmet R. Khademhosseini, Ali |
| Copyright Year | 2014 |
| Description | Journal: Biofabrication Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture. Therefore, it represents an exciting alternative for organ fabrication. Despite the rapid progress in the field, the development of printing processes that can be used to fabricate macroscale tissue constructs from ECM-derived hydrogels has remained a challenge. Here we report a strategy for bioprinting of photolabile cell-laden methacrylated gelatin (GelMA) hydrogels. We bioprinted cell-laden GelMA at concentrations ranging from 7 to 15% with varying cell densities and found a direct correlation between printability and the hydrogel mechanical properties. Furthermore, encapsulated HepG2 cells preserved cell viability for at least 8 days following the bioprinting process. In summary, this work presents a strategy for direct-write bioprinting of a cell-laden photolabile ECM-derived hydrogel, which may find widespread application for tissue engineering, organ printing and the development of 3D drug discovery platforms. |
| Related Links | http://europepmc.org/articles/pmc4040163?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040163/pdf |
| Ending Page | 024105 |
| Page Count | 1 |
| Starting Page | 024105 |
| ISSN | 17585082 |
| e-ISSN | 17585090 |
| DOI | 10.1088/1758-5082/6/2/024105 |
| Journal | Biofabrication |
| Issue Number | 2 |
| Volume Number | 6 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2014-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biofabrication Tissue Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomaterials Biochemistry Bioengineering Biomedical Engineering Biotechnology |
