NDLI: High resolution bioprinting of multi-component hydrogels

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High resolution bioprinting of multi-component hydrogels

Content Provider	Scilit
Author	Zimmermann, Ralf Hentschel, Christoph Schrön, Felix Moedder, Denise Büttner, Teresa Atallah, Passant Wegener, Thomas Gehring, Thomas Howitz, Steffen Freudenberg, Uwe Werner, Carsten
Copyright Year	2019
Description	Journal: Biofabrication Materials capable of directing cell fate by providing spatially-graded mechanical and biomolecular cues are critically important in the reconstitution of living matter. Herein, we report a multi-component inkjet bioprinting method that allows for spatially varying composition and network properties in cell-instructive glycosaminoglycan (GAG)-based biohybrid and pure poly(ethylene glycol) hydrogels with unprecedented (50 µm) resolution. The principle relies on the covalent crosslinking of different polymeric precursors through a very rapid bio-orthogonal Michael type addition scheme adjusted in ways to occur during the fusion of bio-ink droplets prior to and upon contact with the target. Exemplary data show that chemotactic molecular gradients produced by this approach within printed GAG-gels of defined zonal architecture can effectively direct migratory activity and morphogenesis of embedded human bone marrow mesenchymal stem cells. The introduced methodology is expected to enable a new, holistic level of control over reductionistic tissue and organoid models.
Related Links	https://iopscience.iop.org/article/10.1088/1758-5090/ab2aa1/pdf
ISSN	17585082
e-ISSN	17585090
DOI	10.1088/1758-5090/ab2aa1
Journal	Biofabrication
Issue Number	4
Volume Number	11
Language	English
Publisher	IOP Publishing
Publisher Date	2019-06-18
Access Restriction	Open
Subject Keyword	Journal: Biofabrication Introduced Methodology Component Hydrogels
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biochemistry Bioengineering Biomedical Engineering Biotechnology

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