NDLI: Iron Oxide Magnetie-Polyethylene Glycol-Layered Double Hydroxide Core Shell Nanoparticles for Drug Delivery

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Iron Oxide Magnetie-Polyethylene Glycol-Layered Double Hydroxide Core Shell Nanoparticles for Drug Delivery

Content Provider	Scilit
Author	Ebadi, Mona Bullo, Saifullah Hussein, Mohd Zobir
Copyright Year	2018
Description	Journal: Journal of Physics: Conference Series Recently, micro- and nanoparticles with magnetic core and functional shell structures have received much attention because of their potential applications in drug delivery, biosensors catalysis, selective separation and chromatography etc. Layered double hydroxides (LDHs) nanoparticles (NPs) are an efficient cellular delivery vehicle for many negatively charged chemical species. Recently, Mg and Zn/Al-layered double hydroxide (Mg/Al-LDH) and (Zn/Al-LDH) has emerged as a promising nanocarrier for drug delivery system due to its unique properties such as low cytotoxicity, pH-controlled release, good biocompatibility, tunable particle size, and protection of drugs in the interlayer. Various anionic biofunctional molecules, including DNA, SiRNA, drugs and vitamins have been successfully intercalated into LDH interlayers, protected from enzyme degradation and delivered into the cytoplasm in mammalian cells through the clathrin-mediated endocytosis pathway. In this study, a magnetite core shell nanodrug delivery formulation was designed based on $Fe_{3}O_{4}$-PEG-Zn/Al-LHDs or Mg/Al-LDHs loaded with anticancer drug 5-Fluoro-2,4(1H,3H)-pyrimidinedione commonly called 5-fluorouracil. Designed core shell magnetite nanoparticles formulation was characterized using XRD, zeta sizer and high performance liquid chromatography (HPLC).
Related Links	http://iopscience.iop.org/article/10.1088/1742-6596/1082/1/012104/pdf
ISSN	17426588
e-ISSN	17426596
DOI	10.1088/1742-6596/1082/1/012104
Journal	Journal of Physics: Conference Series
Issue Number	1
Volume Number	1082
Language	English
Publisher	IOP Publishing
Publisher Date	2018-08-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Physics: Conference Series Pharmacology and Pharmacy
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy

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