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Layered double hydroxide nanoparticles as an appealing nanoparticle in gene/plasmid and drug delivery system in C2C12 myoblast cells
| Content Provider | Scilit |
|---|---|
| Author | Yazdani, Parivar Mansouri, Elham Eyvazi, Shirin Yousefi, Vahid Kahroba, Homan Hejazi, Mohammad Saeid Mesbahi, Asghar Tarhriz, Vahideh Abolghasemi, Mir Mahdi |
| Copyright Year | 2019 |
| Description | Journal: Artificial cells, nanomedicine, and biotechnology Gene and drug delivery systems need crucial update in the issue of nanocarriers. Layered double hydroxides (LDHs) are known as biocompatible inorganic lamellar nanomaterials with versatile properties. In the present study, Zn/Al-LDH nanoparticle was synthesized and characterized by FTIR, XRD, SEM, TEM and Zeta potential tests and then intercalated with valproate and methyldopa by co-precipitation and ion exchange methods. These nanocarriers were applied as high activity nanolayers-based delivery systems. On the other hand, Zn/Al-LDH + plasmid/gene (pCEP4/Cdk9) evaluated on C2C12 myoblast cells. Co-operation loading indicated high efficiency of sorting and release of drugs. Additionally, the Real-Time PCR and Western blotting results for plasmid-gene (pCEP4/Cdk9) delivery showed that Zn/Al-LDH nanoparticles can be used as an effective carrier in cellular uptake and release of genes for gene therapy. Easy and cost-effective production of Zn/Al-LDH nanoparticles proposed them as potential alternatives for the traditional routs of drug/gene delivery. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/21691401.2018.1559182?needAccess=true |
| Ending Page | 442 |
| Page Count | 7 |
| Starting Page | 436 |
| ISSN | 21691401 |
| e-ISSN | 2169141X |
| DOI | 10.1080/21691401.2018.1559182 |
| Journal | Artificial cells, nanomedicine, and biotechnology |
| Issue Number | 1 |
| Volume Number | 47 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Artificial cells, nanomedicine, and biotechnology Biomaterials Pharmacology and Pharmacy Layered Double Hydroxide Nanomaterial Drug/gene Delivery |
| Content Type | Text |
| Subject | Medicine Biomedical Engineering Biotechnology Pharmaceutical Science |
