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Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes
| Content Provider | Scilit |
|---|---|
| Author | Yao, Litong Zhong, Yifan He, Lingzi Wang, Yan Wu, Jingyang Geng, Jin Zhou, Yun Zhang, Jiahua Chen, Jun Shan, Zhongyan Teng, Weiping Xu, Yingying Chen, Lei Liu, Lei |
| Copyright Year | 2020 |
| Description | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Background: To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes. Methods: A hospital-based cross-sectional study was conducted from February 2012 to November 2018. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. Vision-threatening DR (VTDR) was diagnosed if subjects had severe non-proliferative DR (NPDR), proliferative DR (PDR), or clinically significant macular edema (CSME). Multivariate logistic regression models were applied to explore the associations. Results: Among the 2696 participants, the overall prevalence of DR was 25.1%, of which the prevalence of mild NPDR, moderate NPDR, and VTDR was 10.8%, 4.5%, and 9.9%, respectively. Serum CA125 level was significantly higher in participants with DR and increased with the severity of DR (P = 0.013). After accounting for age, gender, smoking, drinking, duration of diabetes, anti-diabetic agents use, systolic blood pressure, pulse pressure, weight, hemoglobin A1c and fasting plasma glucose levels, CA125 level was significantly associated with subjects in any-severity DR (odds ratio [OR] 1.006 [95% confidence interval CI: 1.002– 1.010], P = 0.006) and VTDR (1.008 [1.003– 1.013], P = 0.001). When CA125 was treated as categorized variables, the prevalence of VTDR might increase as improving CA125 quartiles (P value for trend = 0.017). Conclusion: In this study, serum CA125 level was associated with the presence and severity of DR in Chinese patients with type 2 diabetes. Further prospective studies should be warranted to validate the feasible role of CA125 as well as other biomarkers. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250309/pdf https://www.dovepress.com/getfile.php?fileID=58353 |
| Ending Page | 1812 |
| Page Count | 10 |
| Starting Page | 1803 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s250928 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | ume 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Integrative and Complementary Medicine Diabetes Retinopathy Tumor Biomarker Type 2 Diabetes |
| Content Type | Text |
| Subject | Internal Medicine Pharmacology |
