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Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study
| Content Provider | Scilit |
|---|---|
| Author | Li, Xin Li, Hui-Yao Yu, Zi-Wei Zhang, Yi-Tong Tong, Xue-Wei Gao, Xin-Yuan |
| Copyright Year | 2021 |
| Abstract | Background and Aim: Obesity often coexists with diabetes, especially abdominal obesity, recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of the most common microvascular complications of diabetes, may be associated with these indices. Lipid accumulation product (LAP) and Chinese visceral obesity index (CVAI) are novel visceral obesity indicators, which have been proven to be an influential factor predicting type 2 diabetes (T2DM). However, the correlation among LAP, CVAI, and DR still lacks systematic research in T2DM. The study aimed to explore the relationship among LAP, CVAI levels in different DR stages of T2DM patients and the diagnostic efficacy of LAP and CVAI for DR. Methods: A total of 263 participants were recruited in this cross-sectional study. We enrolled 169 patients with T2DM, divided into the non-DR group (NDR, n = 61), non-proliferative DR group (NPDR, n = 55), and proliferative DR group (PDR, n = 53). And we also enrolled 94 healthy control participants. We collected demographic, anthropometric, and biochemical data on each subject. LAP and CVAI are calculated according to different formulas for men and women. Results: Compared with the control group, LAP and CVAI were significantly higher (P < 0.05). After adjusting for confounding factors, LAP (OR: 1.029, 95CI%: 1.010– 1.049, P < 0.05), WC (OR: 1.073, 95CI%: 1.009– 1.141, P < 0.05) and CVAI (OR: 1.017, 95CI%: 1.000– 1.033, P < 0.05) were all associated with an increased risk of DR. Furthermore, increased LAP (OR: 1.020, 95% CI: 0.100– 0.290) is associated with DR severity (P < 0.001). Moreover, the LAP had the most significant area under the receiver operating characteristics (ROC) curve (AUC) (AUC = 0.728, 95% CI: 0.653– 0.804). Conclusion: A high LAP is associated with an increased risk of DR in T2DM patients, and the LAP index appears to be a good predictor of DR risk and severity in patients with T2DM, compared with BMI, WC, and CVAI. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=77200 |
| Ending Page | 4979 |
| Page Count | 9 |
| Starting Page | 4971 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s348195 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Integrative and Complementary Medicine Womens Studies Obesity Diabetes 95ci Efficacy T2dm Cvai Lap Strong Visceral |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
