NDLI: BAR domain proteins regulate Rho GTPase signaling

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BAR domain proteins regulate Rho GTPase signaling

Content Provider	Scilit
Author	Aspenström, Pontus
Copyright Year	2014
Description	Journal: Small GTPases BAR proteins comprise a heterogeneous group of multi-domain proteins with diverse biological functions. The common denominator is the Bin-Amphiphysin-Rvs (BAR) domain that not only confers targeting to lipid bilayers, but also provides scaffolding to mold lipid membranes into concave or convex surfaces. This function of BAR proteins is an important determinant in the dynamic reconstruction of membrane vesicles, as well as of the plasma membrane. Several BAR proteins function as linkers between cytoskeletal regulation and membrane dynamics. These links are provided by direct interactions between BAR proteins and actin-nucleation-promoting factors of the Wiskott-Aldrich syndrome protein family and the Diaphanous-related formins. The Rho GTPases are key factors for orchestration of this intricate interplay. This review describes how BAR proteins regulate the activity of Rho GTPases, as well as how Rho GTPases regulate the function of BAR proteins. This mutual collaboration is a central factor in the regulation of vital cellular processes, such as cell migration, cytokinesis, intracellular transport, endocytosis, and exocytosis.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/sgtp.28580?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601494/pdf
ISSN	21541248
e-ISSN	21541256
DOI	10.4161/sgtp.28580
Journal	Small GTPases
Issue Number	2
Volume Number	5
Language	English
Publisher	Informa UK Limited
Publisher Date	2014-04-03
Access Restriction	Open
Subject Keyword	Journal: Small GTPases Cell Biology Bar Domain Rho Gtpase
Content Type	Text
Subject	Cell Biology Biochemistry

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