Rho-GTPase signaling drives melanoma cell plasticity

Content Provider	Scilit
Author	Sanz-Moreno, Victoria Marshall, Christopher J.
Copyright Year	2009
Description	To investigate mechanisms that underlie different modes of tumor cell movement we have studied how regulation of the activity of the Rho family GTPases determines the mode of tumor cell movement. Guanine nucleotide exchange factors (GEFs) and GTPase accelerating proteins (GAPs) are key regulators of the activity of small GTPases with GEFs promoting activation to the GTP bound state and GAPs promoting inactivation by stimulating GTP hydrolysis. We identified two important signaling pathways regulating amoeboid and mesenchymal types of motility in melanoma. Here, we discuss our findings in the context of how specificity of Rho signaling is achieved by GEFs and GAPs.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cc.8.10.8490?needAccess=true
Ending Page	1487
Page Count	4
Starting Page	1484
ISSN	15384101
e-ISSN	15514005
DOI	10.4161/cc.8.10.8490
Journal	Cell Cycle
Issue Number	10
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-05-15
Access Restriction	Open
Subject Keyword	Cell Biology Plasticity Signaling Proteins Melanoma Tumor Cell Gtpases
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Biology