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Dexamethasone in the Treatment of the Alcohol Withdrawal Syndrome
| Content Provider | Scilit |
|---|---|
| Author | Adinoff, Bryon Pols, Birgit |
| Copyright Year | 1997 |
| Description | Journal: The American journal of drug and alcohol abuse Pre-clinical studies and clinical case reports suggest that glucocorticoids may be efficacious in ameliorating the signs and symptoms of the alcohol withdrawal syndrome. In order to evaluate the efficacy of the glucocorticoid dexamethasone upon alcohol withdrawal, we administered 4 mg of dexamethasone intravenously to eight alcohol dependent men during withdrawal. Withdrawal severity, as determined by the amount of lorazepam required to ameliorate withdrawal symptoms, was compared to eight other withdrawing patients not administered dexamethasone. There was no significant difference between the two groups in the amount of lorazepam required to treat to withdrawal symptoms. This preliminary study suggests that dexamethasone, in doses expected to suppress hypothalmic-pituitary-adrenal axis activation, is not efficacious in the treatment of alcohol withdrawal. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/00952999709016899 |
| Ending Page | 622 |
| Page Count | 8 |
| Starting Page | 615 |
| ISSN | 00952990 |
| e-ISSN | 10979891 |
| DOI | 10.3109/00952999709016899 |
| Journal | The American journal of drug and alcohol abuse |
| Issue Number | 4 |
| Volume Number | 23 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: The American journal of drug and alcohol abuse Substance Abuse Alcohol Withdrawal Dexamethasone Glucocorticoids |
| Content Type | Text |
| Subject | Clinical Psychology Psychiatry and Mental Health |
