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A novel role for the condensin II complex in cellular senescence
| Content Provider | Scilit |
|---|---|
| Author | Yokoyama, Yuhki Zhu, Hengrui Zhang, Rugang Noma, Ken-Ichi |
| Copyright Year | 2015 |
| Description | Journal: Cell Cycle Although cellular senescence is accompanied by global alterations in genome architecture, how the genome is restructured during the senescent processes is not well understood. Here, we show that the hCAP-H2 subunit of the condensin II complex exists as either a full-length protein or an N-terminus truncated variant (ΔN). While the full-length hCAP-H2 associates with mitotic chromosomes, the ΔN variant exists as an insoluble nuclear structure. When overexpressed, both hCAP-H2 isoforms assemble this nuclear architecture and induce senescence-associated heterochromatic foci (SAHF). The hCAP-H2ΔN protein accumulates as cells approach senescence, and hCAP-H2 knockdown inhibits oncogene-induced senescence. This study identifies a novel mechanism whereby condensin drives senescence via nuclear/genomic reorganization. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/15384101.2015.1049778?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613835/pdf |
| Ending Page | 2170 |
| Page Count | 11 |
| Starting Page | 2160 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.1080/15384101.2015.1049778 |
| Journal | Cell Cycle |
| Issue Number | 13 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-05-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Cell Biology Cellular Senescence Genome Organization Nuclear Architecture Oncogene-induced Senescence |
| Content Type | Text |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
