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Oncogene-induced senescence: An essential role for Runx
| Content Provider | Scilit |
|---|---|
| Author | Kilbey, Anna Terry, Anne Cameron, Ewan R. Neil, James C. |
| Copyright Year | 2008 |
| Description | Oncogene-induced senescence (OIS) is characterised by a stable cell cycle arrest triggered by activated oncogenes and tumour suppressors. Whilst the in vivo relevance of OIS as a mode of tumour suppression is now beyond doubt many key questions with regard to the underlying mechanisms remain unanswered. To address these questions, we first review current knowledge of the essential players and pathways in OIS focussing our discussions mainly on murine cell systems and the paradigm of Ras-induced senescence. We then update experimental evidence for the involvement of the Runx genes that have recently emerged as important mediators of OIS. Of particular interest is the observation that Runx2 disruption renders primary murine embryonic fibroblasts (MEFs) refractory to Ras-induced senescence despite induction of a cascade of growth inhibitors and senescence markers. We suggest that Runx acts downstream of p53 in the "execution phase" of senescence specifically through deregulation of cyclin gene expression. We speculate how this might operate and consider the implications of these findings for the emerging role of the Runx family as tumour suppressors. |
| Related Links | http://europepmc.org/articles/pmc2562501?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562501/pdf |
| Ending Page | 2340 |
| Page Count | 8 |
| Starting Page | 2333 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.6368 |
| Journal | Cell Cycle |
| Issue Number | 15 |
| Volume Number | 7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | Geriatrics Gene Expression Tumour Oncogene Murine Suppressors Induced Senescence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
