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Percutaneous Absorption Enhancement by Nonionic Surfactants
| Content Provider | Scilit |
|---|---|
| Author | Sarpotdar, Pramod P. Zatz, Joel L. |
| Copyright Year | 1986 |
| Description | Journal: Drug Development and Industrial Pharmacy The influence of nonionic surfactants (polysorbates) on hydrocortisone penetration through hairless mouse skin in vitro has been determined. Permeation was quite slow from purely aqueous media containing surfactants following finite dose application. However, if the vehicle contained high propylene glycol concentrations (40% or more), inclusion of a surfactant increased permeation rate significantly. Similar effects were noted following application of a large donor volume (infinite dose). Synergism was attributed to enhancement of surfactant absorption by the stratum corneum leading to changes in skin barrier resistance. With vehicles containing a surfactant, penetration was higher after finite dose application due to compositional changes within the vehicle. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048609042599 |
| Ending Page | 1647 |
| Page Count | 23 |
| Starting Page | 1625 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048609042599 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 11-13 |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1986-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Anesthesiology Nonionic Surfactants Percutaneous Absorption Enhancement Enhancement By Nonionic |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
