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Enhancement of Percutaneous Absorption of Propranolol Hydrochloride by Iontophoresis
| Content Provider | Scilit |
|---|---|
| Author | Nanda, Arun Khar, Roop K. |
| Copyright Year | 1994 |
| Description | Iontophoresis is defined as the migration of ions when an electric current passes through a solution containing ionized species. When applied transdermally, iontophoresis may reduce the barrier porperties of skin and may enhance the transdermal permeation of drugs. This research work was aimed at exploring the factors which influence the effectiveness of iontophoresis facilitated transport of ionized species across the skin, and comparing it with that by passive diffusion. Propranolol hydrochloride was selected as the model drug, and rat abdominal skin as the in-vitro animal model. Pulse dc was applied, at 2.16/3/6/9 mA/cm2; 1:1 or 4:1 duty cycle and 20 KHz frequency for 15/25 minutes. Factors which modify the iontophoretic drug delivery, such as drug concentration, current density, duty-cycle of pulse dc, and duration of iontophoresis, were also evaluated. It was found that iontophoresis causes a significant increase in transdermal permeation of Propranolol hydrochloride in-vitro through rat abdominal skin, as compared to that by passive diffusion. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049409041967 |
| Ending Page | 3044 |
| Page Count | 12 |
| Starting Page | 3033 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049409041967 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 19 |
| Volume Number | 20 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Propranolol Hydrochloride Percutaneous Absorption Enhancement of Percutaneous Hydrochloride By Iontophoresis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
