NDLI: The impact of Agent Orange exposure on presentation and prognosis of patients with chronic lymphocytic leukemia.

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The impact of Agent Orange exposure on presentation and prognosis of patients with chronic lymphocytic leukemia.

Content Provider	Scilit
Author	Kreuziger, Lisa M. Baumann Tarchand, Gobind Morrison, Vicki A.
Copyright Year	2013
Description	Journal: Leukemia & Lymphoma Exposure to Agent Orange (AO) and the contaminating chemical 2,3,7,8-tetrachlorodibenzodioxin (TCDD) has been associated with the development of chronic lymphocytic leukemia (CLL). Of the 195 veterans diagnosed with CLL from 2001 to 2010 in a retrospective cohort from the Minneapolis Veterans Affairs Medical Center, 33 (17%) were exposed to AO. Prognostic factors including Rai stage, lymphocyte doubling time and cytogenetics did not differ between exposed and unexposed patients. Exposed patients were younger at diagnosis (61 vs. 72 years, p < 0.0001) and time to CLL treatment was shorter (9.6 vs. 30.2 months, p = 0.02). Overall survival did not differ between exposed and unexposed patients on Kaplan–Meier analysis, but when adjusted for age, AO exposure had a hazard ratio of death of 1.8 compared to non-exposure (95% confidence interval 0.7–4.5, p = 0.24). The high estimate of the mortality hazard combined with the relatively low numbers in the exposure group suggests that further examination in a larger patient population is warranted.
Related Links	http://europepmc.org/articles/pmc3975330?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975330/pdf
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2013.794267
Journal	Leukemia & Lymphoma
Issue Number	1
Volume Number	55
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-05-07
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Chronic Lymphocytic Leukemia Agent Orange
Content Type	Text
Subject	Hematology Cancer Research Oncology

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