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Use of positron emission tomography-computed tomography in the management of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
| Content Provider | Scilit |
|---|---|
| Author | Conte, Michael J. Bowen, Deborah A. Wiseman, Gregory A. Rabe, Kari G. Slager, Susan L. Schwager, Susan M. Call, Timothy G. Viswanatha, David S. Zent, Clive S. |
| Copyright Year | 2014 |
| Description | Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) cells typically have low $2-deoxy-2-[^{18}$F]fluoro-d-glucose (FDG) avidity, and patients with CLL have an increased risk of developing FDG-avid aggressive lymphomas, second malignancies and infections. We hypothesized that FDG positron emission tomography-computed tomography (PET-CT) of the trunk is a sensitive method of detecting these complications in patients with CLL. Of the of 2299 patients with CLL seen in the Division of Hematology at Mayo Clinic Rochester between 1 January 2006 and 31 December 2011, 272 (11.8%) had 526 PET-CT scans and 472 (89.7%) of these were reported as abnormal. Among the 293 (55.7%) PET-CT scans used for routine evaluation of CLL, the PET component was of clinical value in only one instance. In contrast, in 83 (30.5%) patients, PET-CT scans used to evaluate new clinical complications localized high FDG-avidity lesions for biopsies. This resulted in clinically relevant new diagnoses in 32 patients, including those with more aggressive lymphoma (n = 16), non-hematological malignancies (n = 8) and opportunistic infections (n = 3). Twenty-seven patients had high FDG-avidity CLL, which was associated with prominent lymph node proliferation centers, an increased frequency of poor prognostic factors (17p13 deletion, unmutated immunoglobulin heavy chain variable gene [IGHV], expression of ZAP-70 and CD38) and a shorter overall survival. We conclude that FDG PET scans should not be used for routine surveillance of patients with CLL. However PET-CT scans are sensitive, but not specific, for detection of aggressive lymphomas, other cancers and systemic infections in patients with CLL. |
| Related Links | http://europepmc.org/articles/pmc4419693?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419693/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2013.869801 |
| Ending Page | 2084 |
| Page Count | 6 |
| Starting Page | 2079 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2013.869801 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 9 |
| Volume Number | 55 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-02-17 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Pet Imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
