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Effects of Pulsed Electromagnetic Fields on Human Articular Chondrocyte Proliferation
| Content Provider | Scilit |
|---|---|
| Author | Mattei, Monica De Caruso, Angelo Pezzetti, Furio Pellati, Agnese Stabellini, Giordano Sollazzo, Vincenzo Traina, Gian Carlo |
| Copyright Year | 2001 |
| Description | Journal: Connective tissue research Low-energy, low-frequency pulsed electromagnetic fields (PEMFs) can induce cell proliferation in several cell culture models. In this work we analysed the proliferative response of human articular chondrocytes, cultured in medium containing 10% FBS, following prolonged exposure to PEMFs (75 Hz, 2.3 mT), currently used in the treatment of some orthopaedic pathologies. In particular, we investigated the dependence of the proliferative effects on the cell density, the availability of growth factors and the exposure lengths. We observed that PEMFs can induce cell proliferation of low density chondrocyte cultures for a long time (6 days), when fresh serum is added again in the culture medium. In the same conditions, in high density cultures, the PEMF-induced increase in cell proliferation was observed only in the first three days of exposure. The data presented in this study show that the availability of growth factors and the environmental constrictions strongly condition the cellular proliferative response to PEMFs. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/03008200109016841 |
| Ending Page | 279 |
| Page Count | 11 |
| Starting Page | 269 |
| ISSN | 03008207 |
| e-ISSN | 16078438 |
| DOI | 10.3109/03008200109016841 |
| Journal | Connective tissue research |
| Issue Number | 4 |
| Volume Number | 42 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Connective tissue research Cell Tissue Engineering Proliferation |
| Content Type | Text |
| Subject | Orthopedics and Sports Medicine Cell Biology Molecular Biology Biochemistry Rheumatology |
