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Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana
| Content Provider | Scilit |
|---|---|
| Author | Dotters-Katz, Sarah K. Smid, Marcela C. Manuck, Tracy A. Metz, Torri D. |
| Copyright Year | 2017 |
| Description | Journal: The Journal of Maternal-Fetal & Neonatal Medicine Background: Limited data exist regarding the neonatal and neurodevelopmental outcomes of infants exposed to marijuana (MJ) in-utero, particularly among preterm infants. We hypothesized that MJ-exposed preterm infants would have worse neonatal and childhood developmental outcomes compared to MJ-unexposed infants. Methods: Secondary analysis of multicenter randomized-controlled trial of antenatal magnesium sulfate for the prevention of cerebral palsy was conducted. Singleton nonanomalous infants delivered <35 weeks exposed to MJ in-utero were compared to MJ-unexposed. Primary neonatal outcome was death, grade 3/4 intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, and/or stage II/III necrotizing enterocolitis before discharge. Primary childhood outcome was death, moderate/severe cerebral palsy, or/and Bayley II Scales <70 at age 2. Backward-stepwise regression used to estimate odds of primary outcomes. Results: 1867 infants met inclusion criteria; 135(7.2%) were MJ-exposed. There were no differences in neonatal (20% vs. 26%, p = 0.14) or childhood (26% vs. 21%, p = 0.21) outcomes in MJ-exposed infants compared to MJ-unexposed infants. In adjusted models, MJ-exposure was not associated with adverse neonatal outcomes (aOR 0.83 95% CI 0.47,1.44) or early childhood outcomes (aOR 1.47, 95% CI 0.97,2.23). Conclusions: Among infants born <35 weeks of gestation, MJ-exposure was not associated with adverse neonatal or childhood outcomes. Long-term follow-up studies are needed to assess later childhood neurodevelopmental outcomes following MJ-exposure. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612850/pdf |
| Ending Page | 2939 |
| Page Count | 7 |
| Starting Page | 2933 |
| ISSN | 14767058 |
| e-ISSN | 14764954 |
| DOI | 10.1080/14767058.2016.1269165 |
| Journal | The Journal of Maternal-Fetal & Neonatal Medicine |
| Issue Number | 24 |
| Volume Number | 30 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-01-04 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of Maternal-Fetal & Neonatal Medicine Pediatrics and Child Health Neonatal Morbidity Developmental Outcomes |
| Content Type | Text |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
