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Reversible H-Atom Abstraction from Alcohols by Thiyl Radicals: Determination of Absolute Rate Constants by Pulse Radiolysis
| Content Provider | Scilit |
|---|---|
| Author | Schöneich, Christian Bonifaçcić, Marija Asmus, Klaus-Dieter |
| Copyright Year | 1989 |
| Description | Journal: Free radical research communications Hahn-Meitner-Institut Berlin, Bereich Strahlenchemie, Glienicker Str. 100, 1000 Berlin 39, Fed. Rep. Germany Penicillamine thiyl radicals, PenS', are shown to abstract hydrogen atoms from 2-propanol and to establish an equilibrium PenS' + (CH1)2 CHOH ↔ PenSH + (CH3)2 COH. The rate constants for the forward and back reaction have been determined to (1.4 ± 0.3) × 104 and (1.2 ± 0.3) × 108 M-1 s-1, respectively, by means of pulse radiolysis. The data have been obtained from various independent methods which include direct measurements and competitive schemes involving irreversible interception of the alcohol radical by electron acceptors (e.g. CCl4. PNAP) and/or the thiyl radical by antioxidants (e.g. α-tocopherol). The results demonstrate that the reaction of carbon-centered radicals with thiols, in radiation biology commonly known as “repair” reaction, may be reversed and thus imply the possibility of thiyl radical induced biological damage. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10715768909087923 |
| Ending Page | 405 |
| Page Count | 13 |
| Starting Page | 393 |
| ISSN | 87550199 |
| DOI | 10.3109/10715768909087923 |
| Journal | Free radical research communications |
| Issue Number | 6 |
| Volume Number | 6 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1989-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Free radical research communications Atomic, Molecular and Chemical Physics Thiyl Radicals Reversible H-atom Abstraction Pulse Radiolysis |
| Content Type | Text |
| Subject | Biochemistry |
