NDLI: Long-term follow-up of phase II trial of docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small cell lung cancer

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Long-term follow-up of phase II trial of docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small cell lung cancer

Content Provider	Scilit
Author	Tokuda, Yoshiyuki Takigawa, Nagio Kozuki, Toshiyuki Kamei, Haruhito Bessho, Akihiro Tada, Atsuhiko Hotta, Katsuyuki Katsui, Kuniaki Kanazawa, Susumu Tanimoto, Mitsune Kiura, Katsuyuki
Copyright Year	2011
Description	Journal: Acta Oncologica Chemoradiation improves survival for patients with locally advanced non-small cell lung cancer (NSCLC), but clinical outcomes beyond five years are rarely reported. The aim of the present study was to identify the long-term results of a phase II study of docetaxel and cisplatin with concurrent thoracic radiation. We previously reported short-term outcomes from the phase II study, which enrolled 42 patients (aged ≤ 75 years) with unresectable stage III NSCLC. We continued to follow these patients for long-term clinical outcomes. At a median follow-up for all patients of 6.3 years (range: 5.2-7.1 years), the median survival time was 2.1 years and the actual five-year survival rate was 31%. Among 14 patients who were progression-free longer than two years, three patients died due to bacterial or fungal pneumonia and one died due to gall bladder cancer. Thirty-one percent of locally advanced patients having NSCLC treated with docetaxel and cisplatin and concurrent thoracic radiation survived beyond five years. Progression-free patients might be cautiously followed up taking precautions against emerging pneumonia.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/0284186X.2011.631580
Ending Page	540
Page Count	4
Starting Page	537
ISSN	0284186X
e-ISSN	1651226X
DOI	10.3109/0284186x.2011.631580
Journal	Acta Oncologica
Issue Number	4
Volume Number	51
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-11-16
Access Restriction	Open
Subject Keyword	Journal: Acta Oncologica Respiratory System Patients with Locally Advanced
Content Type	Text
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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