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Radiation Therapy and Concurrent Cisplatin Administration in Locally Advanced Head and Neck Cancer a Hellenic Co-Operative Oncology Group Study
| Content Provider | Scilit |
|---|---|
| Author | Fountzilas, George Skarlos, Dimosthenis Samantas, Epaminontas Kalogera-Fountzila, Anna Papaspyrou, Spyros Tzitzikas, John Sridhar, Kasi S. Pantelakos, Panayiotis Nikolaou, Angelos Bacoyiannis, Haralambos Sinodinou, Maria Banis, Constantinos Daniilidis, John |
| Copyright Year | 1994 |
| Description | Journal: Acta Oncologica In an attempt to improve local control of locally advanced head and neck cancer, radiation therapy was combined with cisplatin. Forty-eight patients entered into this study. All patients were irradiated with a 60Co unit and according to the protocol they should receive 70 Gy in the tumor area and 45 Gy in the rest of neck. Cisplatin was administered at a dose of 100 mg/m2 on days 2, 22 and 42. Thirty-seven (80%) patients received the total radiation dose as initially planned. Thirty-four (72%) patients achieved complete and 5 (10%) partial response. Grade 3-4 toxicities included vomiting (14%), stomatitis (4%), diarrhea (2%), myelotoxicity (14%), hoarseness (4%), dysphagia (30%), weight loss (32%), nephrotoxicity (4%) and dermatitis (2%). After a median follow-up of 26 (range, 18-33) months, 16 patients have died. Among the 35 complete responders 6 later on relapsed. Median relapse-free survival has not yet been reached. Combined radiation therapy and cisplatin appears to be a highly active treatment in patients with advanced head and neck cancer as far as primary locoregional response is concerned. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/02841869409083955 |
| Ending Page | 830 |
| Page Count | 6 |
| Starting Page | 825 |
| ISSN | 0284186X |
| e-ISSN | 1651226X |
| DOI | 10.3109/02841869409083955 |
| Journal | Acta Oncologica |
| Issue Number | 7 |
| Volume Number | 33 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1994-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Acta Oncologica Radiology, Nuclear Medicine and Imaging Radiation Therapy Head and Neck Cancer Concurrent Cisplatin Cisplatin Administration |
| Content Type | Text |
| Subject | Radiology, Nuclear Medicine and Imaging Hematology Oncology |
