NDLI: The Regulation Of The Aging Immune Response By Auto-Anti-Idiotypic Antibody*

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The Regulation Of The Aging Immune Response By Auto-Anti-Idiotypic Antibody*

Content Provider	Scilit
Author	Goidl, E. A.
Copyright Year	2018
Description	This chapter shows how the balance between positive and negative autoimmunity changes during the life of the animal and is regulated by the production of auto-anti-idiotypic antibody (auto-anti-Id). The increase in the production of auto-anti-Id in the aging immune response could be due to the recognition of a larger proportion of anti-trinitrophenylated idiotopes or, alternatively, a reduced heterogeneity of clonotypes responding to the antigenic determinant assay could contribute to this phenomenon. To determine the cellular regulation of the production of auto-anti-Id in the aged immune response, we first established whether this increase was a trait which was stable upon cell transfer. After removal of auto-anti-Id, antiself-reactivity in the immune cell population obtained from young mice was found to increase modestly. In contrast, removal of auto-anti-Id from aged immune spleen cells led to an increase in anti-self-reactivity ranging from 28 to 42%. Still, these results are as yet inconclusive in determining the exact origin of the anti-self-reactivities. Book Name: Biological Applications of Anti-Idiotypes
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781351070225-11&type=chapterpdf
Ending Page	176
Page Count	12
Starting Page	165
DOI	10.1201/9781351070225-11
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-01-18
Access Restriction	Open
Subject Keyword	Book Name: Biological Applications of Anti-idiotypes Antibody Auto Anti Aged Immune Antigenic Idiotypic Removal Aging Immune Response
Content Type	Text
Resource Type	Chapter

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