NDLI: Modulation Of The Immune System Towards Antiviral Immune Response Using Anti-Idiotypic Structures

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Modulation Of The Immune System Towards Antiviral Immune Response Using Anti-Idiotypic Structures

Content Provider	Scilit
Author	Osterhaus, A. D. M. E. Bunschoten, E. J. Weijer, K. Haag, F. G. C. M. Uytde
Copyright Year	2018
Description	This chapter reviews different approaches of using anti-Id antibody for the modulation of the immune response to a number of relevant human and animal virus infections. Based upon the network concept of the immune system initially proposed by N. K. Jerne, have implicated the exploitation of elements of the immune system itself — antiidiotype (anti-Id) antibodies — to replace "external" antigens for vaccination. However, in the reovirus III system and in the Sendai virus system, it was shown that MoAb2 directed to either a B- or a T-cell idiotope induced both a B- and T-cell-mediated antiviral immunity, which in the latter also proved to be protective against virus challenge. The first report on a candidate internal image in a viral system came, from Urbain's group using antitobacco mosaic virus (TMV) capsid protein as an antigen. They described a rabbit $Ab_{2}$ which recognized an interspecies cross-reacting Id present on anti-TMV antibodies from rabbits, mice, horses, goats, and chickens immunized with TMV. Book Name: Biological Applications of Anti-Idiotypes
Related Links	https://api.taylorfrancis.com/content/chapters/edit/download?identifierName=doi&identifierValue=10.1201/9781351070225-2&type=chapterpdf
Ending Page	22
Page Count	10
Starting Page	13
DOI	10.1201/9781351070225-2
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-01-18
Access Restriction	Open
Subject Keyword	Book Name: Biological Applications of Anti-idiotypes Urban Studies Antiviral Antibodies Antigen Virus Horses Vaccination Tmv Rabbits Modulation
Content Type	Text
Resource Type	Chapter

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