NDLI: Design and Evaluation of a Lorazepam Transdermal Delivery System

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Design and Evaluation of a Lorazepam Transdermal Delivery System

Content Provider	Scilit
Author	Costa, Paulo Jorge Cardoso da Ferreira, Domingos Morgado, Rui Lobo, J. M. Sousa
Copyright Year	1997
Description	Journal: Drug Development and Industrial Pharmacy The aim of this work was to study the release and the permeation rate of lorazepam, in order to develop a transdermal therapeutic system (TTS) containing that drug. Only a small number of drugs are by themselves able to permeate the skin at a useful rate in order to achieve a therapeutic effect. The lorazepam permeation rate did not reach that value and required a skin permeation enhancer to increase the skin's permeability. Three permeation enhancers (Tween 80, sodium lauryl sulfate, and benzalkonium chloride) were investigated in two different concentrations: 1% and 5% of the amount of lorazepam. The best permeation enhancement results were obtained using benzalkonium chloride in concentration of 5%.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049709149144
Ending Page	944
Page Count	6
Starting Page	939
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049709149144
Journal	Drug Development and Industrial Pharmacy
Issue Number	10
Volume Number	23
Language	English
Publisher	Informa UK Limited
Publisher Date	1997-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Anesthesiology Permeability Benzalkonium
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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