Loading...
Please wait, while we are loading the content...
Similar Documents
Controlled Transdermal Mucolytic Delivery System
| Content Provider | Scilit |
|---|---|
| Author | Thassu, Deepak Vyas, S. P. |
| Copyright Year | 1991 |
| Description | Bromhexine a mucolytic agent was studied to explore for dermal route of administration. The formulations were based on commercial eudragit polymers and polyvinyl pyrrolidone. Two systems i.e., Matrix and Pseudolatex were studied for their comparative performance evaluation in in vitro. The various combinations of hydrophobic (Eudragit RL-100) and hydrophilic (PVP 40,000) polymers were used to prepare the both matrix and pseudolatex topical systems. The prepared systems were studied for in vitro diffusion using a Franz diffusion cell. Study revealed that the relative concentration of hydrophobic to hydrophilic polymers determines the drug diffusion and across the skin permeation of the drug. Both the systems were noted to be stable, however, the drug release and across the skin permeability of drug from pseudolatex system recorded to be better and uniform. Preliminary studies on bromhexine are indicative of its potentiality for transdermal preparation and establish the need for in vivo evaluation. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049109044263 |
| Ending Page | 576 |
| Page Count | 16 |
| Starting Page | 561 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049109044263 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 4 |
| Volume Number | 17 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Anesthesiology Mucolytic Delivery Controlled Transdermal Mucolytic Delivery System |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
