NDLI: Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer

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Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer

Content Provider	Scilit
Author	Yang, Jiaxing Teng, Yongliang Fu, Yu Zhang, Chunyu
Copyright Year	2019
Description	Journal: International Journal of Nanomedicine Background: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents. Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells. Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer. Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6. Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628142/pdf https://www.dovepress.com/getfile.php?fileID=51071
Ending Page	5071
Page Count	11
Starting Page	5061
e-ISSN	11782013
DOI	10.2147/ijn.s202910
Journal	International Journal of Nanomedicine
Volume Number	ume 14
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-07-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Biomaterials Pharmacology and Pharmacy Cell Membrane Gastric Cancer Photodynamic Therapy Silica Nanoparticles
Content Type	Text

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